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Ee plasmin and SK-plasmin complexes were inhibited by a specific plasmin inhibitor to avoid cross-reaction with the substrate. Hydrolysis was determined at 405 nm, and the M49 sample without inhibitor was set as 100 . The results are shown as means of at least three independent experiments with fresh frozen plasma from different donors (A) or pooled normal plasma (C and D) the SD. **, P 0.01; ***,

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