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Lays a significant role in the replication of viral DNA in vivo. SV40 tAg has been found to interact with PP2A, and it is predicted to bind Hsc70. In addition to these two cellular proteins, JCV tAg binds to the viral agnoprotein and to the Rb proteins, pRB, p107 and p130, most likely via two unique LxCxE motifs. Cooperation between the LxCxE and J domains of JCV tAg are expected to influence cell

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