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Promoting a pro-apoptotic environment [13,15-20]. Independent of its interaction with thioredoxin, TXNIP also has the ability to inhibit cell cycle progression by indirectly stabilizing the cell cycle inhibitor p27Kip1 [9]. In addition, TXNIPMorrison et al. Molecular Cancer 2014, 13:62 8 ofAvectorB*** *TXNIPCD******Figure 5 TXNIP overexpression in

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